Impact of Luteal Phase Injection by Single Dose Gonadotropin-Releasing Hormone Agonist in Women Undergoing Intra Uterine Insemination

Objective: To assess the effect of GnRHa as luteal phase support in women undergoing controlled ovarian stimulation and IUI. Design: A prospective, randomized trial. Setting: Cytogenetic and Endoscopy Unit, Zagazig University Hospital. Methods: Two hundred fourteen women either with unexplained or mild male factor infertility was planned to contribute to this study. After exclusion 18 women, 196 couples were assigned into two groups: GnRHa (study group, n = 98) were receiving Single dose of 0.1 mg of Triptorelin by SC injection 8 days after the insemination while non GnRHa (the control group, n = 98) were not receiving injection as luteal phase support. Results: Serum progesterone levels at 10 days after IUI was statistically significantly increased in the GnRHa group than in non GnRHa group (p < 0.001), while, there were no significant differences between both groups in serum Progesterone level before triggering and 7 days after insemination. Pregnancy rates per cycle were (18.94% for GnRHa and 17.39% for non GnRHa group respectively (P = 0.78). Conclusions: Luteal phase GnRHa administration can increase the progesterone level and consequently the luteal phase duration, with increase in the pregnancy rate in the GnRHa group but did not reaching the statistical significant level.